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PRODID:-//Memento EPFL//
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SUMMARY:Hypoxia and obesity
DTSTART:20150415T133000
DTEND:20150415T143000
DTSTAMP:20260510T135148Z
UID:f258fec28b5fb8a9231d1ab062d475a1d069d845cc66b37e21094823
CATEGORIES:Conferences - Seminars
DESCRIPTION:Bengt KAYSER (UNIL)\nHigh altitude exposure is often accompani
 ed by weight loss. Postulated mechanisms are a reduction of nutritional en
 ergy intake\, a reduction of intestinal energy uptake from impaired intest
 inal function and increased energy expenditure. Beyond the field of altitu
 de\, there are good reasons for renewed interest in the relationship betwe
 en hypoxia and energy balance. The increasing prevalence of obesity and as
 sociated comorbidities represent a major health concern. Obesity is freque
 ntly associated with sleep disorders leading to intermittent systemic hypo
 xia with deleterious cardiovascular and metabolic consequences. Hypoxic re
 gions may be present within hypertrophic white adipose tissue leading to c
 hronic systemic inflammation. Among the increasing number of people commut
 ing to altitude for work or leisure\, obesity is a risk factor for acute m
 ountain sickness. Paradoxically\, exposure to intermittent hypoxia might b
 e considered as a means to lose body mass and to improve metabolic risk fa
 ctors. Daytime exposure to intermittent hypoxia has been used to treat hyp
 ertension in former Soviet Union countries and is now being experimented e
 lsewhere. Such intermittent hypoxic exposure at rest or during exercise ma
 y lead to improvement in body composition and health status with improved 
 exercise tolerance\, metabolism and systemic arterial pressure. Future res
 earch should confirm whether hypoxic training could be a new treatment str
 ategy for weight loss and comorbidities in obese subjects and elucidate th
 e underlying mechanisms and signalling pathways.
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STATUS:CONFIRMED
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