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SUMMARY:Scanning Ion Conductance Microscopy of Soft Biological Matter
DTSTART:20150504T121500
DTSTAMP:20260427T224113Z
UID:75b4a2b8e318613a3b3392ccbacdf63f0186b98af22c170c140b7248
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Yuri Korchev\, Imperial College\, London (UK)\nDISTINGUI
 SHED LECTURE IN BIOLOGICAL ENGINEERINGAbstract\nMolecular Biology has adva
 nced and we know much about the individual molecular components that make 
 up living cells down to the level of the individual atoms. The challenge\,
  however\, is to fully understand the functional integration of these comp
 onents. This requires determining how the molecular machines that make up 
 a living cell are organized and interact together not at the atomic length
  scale but on a nm scale. To do this we need to develop and applying nanos
 cale techniques for the visualization and quantification of cell machinery
  in real-time and on living cells. This will lead to detailed\, quantitati
 ve models of sub-cellular structures and molecular complexes under differe
 nt conditions for both normal and diseased cells.\nThis approach ultimatel
 y requires the development of novel biophysical methods. We have recently 
 pioneered the development of an array of new and powerful biophysical tool
 s based on Scanning Ion Conductance Microscopy [1\, 2] that allow quantita
 tive measurements and non-invasive functional imaging of single protein mo
 lecules in living cells [3]. Scanning ion conductance microscopy and a bat
 tery of associated innovative methods are unique among current imaging tec
 hniques\, not only in spatial resolution of living and functioning cells [
 4]\, but also in the rich combination of imaging with other functional and
  dynamical interrogation methods (e.g electrophysiological recording from 
 presynaptic boutons [5]). These methods\, crucially\, will facilitate the 
 study of integrated nano-behaviour in living cells in health and disease.\
 n[1]  P. K. Hansma\, B. Drake\, O. Marti\, S. A. Gould\, C. B. Prater\, S
 cience 243\, 641 (1989).\n[2]  Y. E. Korchev\, C. L. Bashford\, M. Milova
 novic\, I. Vodyanoy\, M. J. Lab\, Biophys. J. 73\, 653 (1997).\n[3]  A. I
 . Shevchuk et al.\, Angew. Chem. Int. Ed Engl. 45\, 2212 (2006).\n[4]  P.
  Novak et al.\, Nat. Methods 6\, 279 (2009).\n[5]  P Novak\, et al.\, Neu
 ron\, 79\, 1067 (2013)Bio:\nProf Yuri Korchev gained a BSc in Biology & Ph
 ysiology\, a Diploma in University Teaching\, and an MSc in Physiology\, a
 t the University of St Petersburg\, and a PhD (biophysics of ion transport
 ) at the Russian Academy of Sciences. From 1984\, he held the post of Rese
 arch Scientist at the Institute of Cytology\, Russian Academy of Sciences\
 , St Petersburg. In 1991 he joined St George's Hospital Medical School\, L
 ondon as a Wellcome Trust Research Fellow and then as a Post-Doctoral Rese
 arch Fellow. In 1995 he moved to Charing Cross & Westminster Medical Schoo
 l as a Post-Doctoral Research Fellow\, and in 1997 became a lecturer at Im
 perial College School of Medicine\, Division of Medicine\, Hammersmith Cam
 pus. In 2003\, Yuri was appointed as Reader and in 2005 as Professor of Bi
 ophysics. He now heads the Nanomedicine laboratory at Imperial College Lon
 don.Yuri is non-executive Chief Scientist of Ionoscope limited.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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