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SUMMARY:High-Throughput and Ultra-Sensitive Optical Bio-Nanosensors 
DTSTART:20150417T141500
DTSTAMP:20260415T200420Z
UID:21c42bf2bd6b682e1d53130973e0737f5a0813fe4b969613e322f4c7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Hatice Altug\, Bionanophotonic Systems Laboratory\, Inst
 itute of Bioengineering\, EPFL\nNew healthcare initiatives\, such as perso
 nalized medicine\, point-of-care and early disease diagnostics require bre
 akthrough developments in biosensing technologies.\nUnfortunately\,current
  biosensors are unsuitable because they are time consuming\, costly\, bulk
 y and require advanced infrastructure and trained professionals.\nTo meet 
 the needs\, Altug’s lab (BIOS) is developing cutting edge on-chip optica
 l bio-detection and spectroscopy systems by exploiting nano-scale photonic
 s\, nano/microfluidics\, and nanotechnology.\nIn a recent work\, BIOS intr
 oduced a high-throughput and label-free protein microarray technology with
  nearly one million sensor elements that enable reliable and quantitative 
 detection of biomolecules. By coupling wide-field plasmonic arrays with a 
 lens-free computational on-chip imaging they demonstrated hand-held\, ligh
 tweight and low-cost diagnostic tools for point-of-care applications.\nThe
  sensor is based on metallic nanohole arrays and exploits highly sensitive
  plasmonically enabled extra-ordinary optical transmission.\nBIOS showed t
 hat such optical sensors can detect live and intact viruses in biological 
 media at medically relevant concentrations.\nBy uniquely integrating nanof
 luidics and nano-optics on the same platform\, they introduced a method to
  overcome mass-transport problem severely limiting sensor performance at l
 ow-analyte concentration and dramatically shortened required detection tim
 e.\nBIOS is also working on an ultrasensitive and label-free mid-infrared 
 biosensors which can fingerprint vital biomolecules such as proteins and l
 ipids by accessing their chemical specific absorption bands. Engineering s
 culptured on-chip infrared nano-antennas that support strong light-matter 
 interactions\, the lab demonstrated that fundamental Beer-Lambert law can 
 be overcome and the weak protein absorption signals can be enhanced by mor
 e than 10\,000 times. By using extreme field concentration of nano-optics\
 , BIOS showed real-time and in-situ monitoring of biomolecular interaction
 s from ultra-low quantities of molecules. BIOS’s technologies are openin
 g up new paradigms in ultra-sensitive vibrational spectroscopy for biology
 .
LOCATION:PH L1 503 (Aquarium) http://plan.epfl.ch/?room=PHL1503
STATUS:CONFIRMED
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