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SUMMARY:“The role of the Nrf2 transcription factor in liver homeostasis 
 and regeneration”
DTSTART:20150512T100000
DTEND:20150512T110000
DTSTAMP:20260920T142715Z
UID:7c8920551077ec4f4d4efca18c1989935d29b589406c6736f3c18bfc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ulrike Köhler\, Institute of Molecular Health Sciences\, ETHZ
 \, Zurich (CH)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITI
 ON ALLIANCE (LIMNA)Abstract:\nOxidative stress inhibits liver regeneration
  and plays a crucial role in the development of chronic liver disease. As 
 pharmacological activation of the antioxidant Nrf2 transcription factor is
  a promising strategy to prevent toxin-induced liver damage\, we aimed to 
 study effects of continous Nrf2 activation in the liver. We analysed mice 
 expressing a constitutively active Nrf2 mutant in hepatocytes and found un
 expected deleterious effects on liver regeneration. Furthermore\, we gener
 ated mice lacking both Nrf2 and p65/RelA signalling in hepatocytes to iden
 tify potential complementary cytoprotective functions. These mice develope
 d spontaneous liver inflammation and fibrosis\, providing evidence for a f
 unctional interaction of Nrf2 and NF-kB signaling in the liver in vivo.”
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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