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SUMMARY:Three computational experiments to assess error propagation in bio
 logical sequence annotations
DTSTART:20100422T121500
DTSTAMP:20260407T063906Z
UID:54882e70d722ceae63b5b5e6b6fcf644a02465b50469603cb2d4676c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Marco Pagni\, Vital IT\, Swiss Institute of Bioinformatics\
 , Lausanne\nDue to the rapid release of new data from genome sequencing pr
 ojects\, the majority of sequences in public databases have not been exper
 imentally characterized. Sequences are annotated using the diverse in sili
 co methods available. The level of misannotation and the types of misannot
 ations generated by these methods are difficult to establish\, but they ar
 e clearly not negligible and are sometimes steadily propagated once in the
  public domain. During this seminar\, three test cases will be presented: 
 (i) The genetic map of Bacillus subtilis 168\; (ii) The classification of 
 protein sequences with modular architecture\; (iii) The multiple amino aci
 d auxotrophies of the fungal pathogen Pneumocystis carinii In each case\, 
 it will be shown that a computational experimentation proved very helpful 
 to deal with the burden provoked by error propagation. Sound biological co
 nclusions can be established\, despite the poorly characterized "noise" pr
 esent in the starting material.
LOCATION:SV 1717A
STATUS:CONFIRMED
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