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SUMMARY:Holographic endo-microscopy based on multimode waveguides
DTSTART:20150507T100000
DTSTAMP:20260407T230511Z
UID:aa4dbba3cf02cd4f1117ca6551e8be592f51caa9fbc4015eacaabff6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Tomas Cizmar\, University of Dundee\, Scotland\nSmall\, fi
 bre-based endoscopes have already improved our ability to image deep withi
 n the humanbody. Current fibre-based devices consist of fibre-bundles in w
 hich individual fibres represent single pixels of the transmitted image. A
  novel approach introduced recently1 utilized disordered light within a st
 andard multimode optical fibre for lensless imaging. Importantly\, this ap
 proach brought very significant reduction of the instrument’s footprint 
 to dimensions below 100μm. Such device may be used for imaging of structu
 res deep inside living organisms directly through centimeters of living ti
 ssues without bringing about their extended collateral damage. In Neurosci
 ence\, this technology may assist to address important unanswered question
 s related to formation and recall of memories as well as onset and progres
 sion of severe neuronal disorders such as Alzheimer’s disease.The two mo
 st important limitations of this exciting technology are (i) the lack of b
 ending flexibility (imaging is only possible as long as the fibre remains 
 stationary) and (ii) high demands on computational power\, making the perf
 ormance of such systems slow.We discuss routes to allow flexibility of suc
 h endoscopes by broader understanding of light transport processes within.
  We show that typical fibers retain highly ordered propagation of light ov
 er remarkably large distances\, which allows correction operators to be in
 troduced in imaging geometries in order to maintain high-quality performan
 ce even in such flexible micro-endoscopes. Separately\, we introduce a GPU
  toolbox2 to make these technique faster and accessible to researchers. Th
 e toolbox optimizes acquisition time of the transformation matrix of the f
 ibre by synchronous operation of CCD and SLM.Further\, it uses the acquire
 d transformation matrix retained within the GPUmemory to generate any desi
 red holographic mask for on-the-fly modulation of the output light fields.
  We demonstrate the functionality of the toolbox bydisplaying an on-demand
  oriented cube\, at the distal end of the fibre with refresh-rate of 20ms.
 \nBio: Though my scientific background is Physics\, throughout my scientif
 ic career I took part in a variety of inter-disciplinary projects in Bio-M
 edical Photonics\, mostly related to optical manipulation\, digital hologr
 aphy\, microscopy and cell biology.\nMy recent research activities are foc
 used on Photonics in random environments and highly turbid media such as b
 iological tissues or multimode waveguides.\n·         2003 - 2006
  - PhD at the Institute of Scientific Instruments & Masaryk University\, B
 rno\, Czechia\n·         2007 - 2010 - PDRA at School of Physics 
 and Astronomy\, University of St Andrews\, Scotland\, UK\n·       
   2010 - 2013 - Academic research fellow at School of Medicine\, Universi
 ty of St Andrews\, Scotland\, UK\n·         2013 onwards - Reader
  in Physics & Life Sciences\, University of Dundee\, Scotland\, UK
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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