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SUMMARY:Scanning Ion Conductance Microscopy of Soft Biological Matter
DTSTART;VALUE=DATE:20150504
DTSTAMP:20260916T043447Z
UID:d198171320c65b041d8da3812a4c3202e847498205ceeb2563b28b8d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Yuri Korchev\, Imperial College London\nMolecular Biolog
 y has advanced we know much about the individual molecular components that
  make up living cells down to the level of the individual atoms. The chall
 enge\, however\, is to fully understand the functional integration of thes
 e components. This requires determining how the molecular machines that ma
 ke up a living cell are organized and interact together not at the atomic 
 length scale but on a nm scale. To do this we need to develop and applying
  nanoscale techniques for the visualization and quantification of cell mac
 hinery in real-time and on living cells. This will lead to detailed\, quan
 titative models of sub-cellular structures and molecular complexes under d
 ifferent conditions for both normal and diseased cells.\nThis approach ult
 imately requires the development of novel biophysical methods. We have rec
 ently pioneered the development of an array of new and powerful biophysica
 l tools based on Scanning Ion Conductance Microscopy [1\, 2] that allow qu
 antitative measurements and non-invasive functional imaging of single prot
 ein molecules in living cells fig. 1 [3]. Scanning ion conductance microsc
 opy and a battery of associated innovative methods are unique among curren
 t imaging techniques\, not only in spatial resolution of living and functi
 oning cells fig. 2 [4]\, but also in the rich combination of imaging with 
 other functional and dynamical interrogation methods (e.g electrophysiolog
 ical recording from presynaptic boutons fig. 2 [5]). These methods\, cruci
 ally\, will facilitate the study of integrated nano-behaviour in living ce
 lls in health and disease.\n[1]    P. K. Hansma\, B. Drake\, O. Marti\,
  S. A. Gould\, C. B. Prater\, Science 243\, 641 (1989).\n[2]    Y. E. K
 orchev\, C. L. Bashford\, M. Milovanovic\, I. Vodyanoy\, M. J. Lab\, Bioph
 ys. J. 73\, 653 (1997).\n[3]    A. I. Shevchuk et al.\, Angew. Chem. In
 t. Ed Engl. 45\, 2212 (2006).\n[4]    P. Novak et al.\, Nat. Methods 6\
 , 279 (2009).\n[5]    P Novak\, et al.\, Neuron\,79\, 1067 (2013)\nBio:
  Prof Yuri Korchev gained a BSc in Biology & Physiology\, a Diploma in Un
 iversity Teaching\, and an MSc in Physiology\, at the University of St Pet
 ersburg\, and a PhD (biophysics of ion transport) at the Russian Academy o
 f Sciences. From 1984\, he held the post of Research Scientist at the Inst
 itute of Cytology\, Russian Academy of Sciences\, St Petersburg. In 1991 h
 e joined St George's Hospital Medical School\, London as a Wellcome Trust 
 Research Fellow and then as a Post-Doctoral Research Fellow. In 1995 he mo
 ved to Charing Cross & Westminster Medical School as a Post-Doctoral Resea
 rch Fellow\, and in 1997 became a lecturer at Imperial College School of M
 edicine\, Division of Medicine\, Hammersmith Campus. In 2003\, Yuri was ap
 pointed as Reader and in 2005 as Professor of Biophysics. He now heads the
  Nanomedicine laboratory at Imperial College London.Yuri is non-executive 
 Chief Scientist of Ionoscope limited.
LOCATION:SV1717a http://plan.epfl.ch/?lang=fr&room=SV1717a
STATUS:CONFIRMED
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