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SUMMARY:Using Scaling Laws to Predict the Response of Resistant Microbes a
 nd Cancer Cells to Drug Cocktails
DTSTART:20150505T100000
DTSTAMP:20261003T205330Z
UID:a09af323bcf6e831a23ded59a9040dbe3595184ffd0ddf12b2136b0a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Philippe Cluzel\, Harvard University\, Cambridge\, MA (U
 SA)\nBIOENGINEERING SEMINARAbstract:\nAn outstanding problem in modern med
 icine is combating bacteria that are resistant to antibiotics\, and cancer
  cells resistant to chemotherapy treatments. While drug combinations are o
 ften used to counter resistance\, therapies developed on drug-sensitive ce
 lls mostly fail when applied to resistant mutants. Here I will describe a 
 series of experiments and theoretical arguments to show that scaling laws 
 allow us to infer the behavior of resistant mutants from that of drug-sens
 itive cells. Experiments validate these scaling laws\, which hold for many
  cell types across several domains of life. This approach was found to eff
 ectively identify potent dosage regimes for targeting resistant mutants wi
 thout any prior knowledge of their specific resistance mechanisms in bacte
 ria\, yeast\, and cancer cell lines.\nOne advantage of using frameworks ba
 sed on engineering principles to predict cellular behavior is that they de
 pend on the general systems’ properties and symmetry arguments rather th
 an on mechanistic molecular details. Unifying approaches like this provide
  an opportunity to reveal the potential simplicity of cellular behaviors t
 hat are often confounding at the molecular level.Bio:\nDr. Cluzel received
  his PhD in Physics from Institut Marie Curie\, Paris (F)\, in 1996. He wa
 s a postdoctoral researcher in Physics and Molecular Biology at Princeton 
 University (Leibler Lab) until 2000\, then Assistant (2000-2007) and later
  (2007-2008) Associate Professor of Physics at the University of Chicago.\
 nSince 2008 he is Full Professor of Molecular Cell Biology at Harvard Univ
 ersity's Faculty of Arts & Sciences (Department of Molecular and Cellular 
 Biology) and Center for Systems Biology\, and is Gordon McKay Professor of
  Applied Physics in the School of Engineering and Applied Sciences.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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