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SUMMARY:Decoding Molecular Plasticity in the Dark Proteome
DTSTART:20150519T093000
DTSTAMP:20260407T010615Z
UID:1a00555ad3f20afd7c78a6a97eb3394b001e6e473e8aca3343169b27
CATEGORIES:Conferences - Seminars
DESCRIPTION:Edward A. Lemke\, Ph.D.\, European Molecular Biology Laborator
 y EMBL\, Heidelberg (D)\nBIOENGINEERING SEMINARAbstract:\nThe focus of our
  research lies on intrinsically disordered proteins (IDPs)\, which constit
 ute up to 50% of the eukaryotic proteome. IDPs are enriched e.g. in vital 
 processes like epigenetic mechanisms\, nucleocytoplasmic transport and tra
 nscription. In addition\, IDPs are flexible protein biopolymers\, and thei
 r plasticity encodes much unexplored potential for bio-inspired material s
 cience research. While the ability of IDPs to sample multiple conformation
 s is considered a major driving force behind their evolution as multifunct
 ional hubs in eukaryotes\, studying biological machineries enriched in suc
 h dynamic proteins imposes a major obstacle for conventional technologies 
 (thus constituting what is termed the “Dark (invisible) Proteome”). I 
 will show that fluorescence tools are ideally suited to study IDPs\, since
  their non-invasive character permits smooth transition between biochemica
 l and cellular studies. In particular\, single molecule and superresolutio
 n techniques are powerful tools for studying spatial and temporal heteroge
 neities that are intrinsic to complex biological systems\, as they provide
  an unbiased view on the underlying mechanisms. I will show that key to su
 cceeding with this goal is to synergistically combine this effort with adv
 anced tool development\, in particular in chemical and synthetic biology a
 s well as lab-on-a-chip miniaturization efforts\, to increase strength and
  sensitivity of the approach as a whole. I will present our most recent ad
 vances on understanding the molecular plasticity and multivalency of nucle
 oporins in the transport pathway. Furthermore\, I will talk about a new ge
 neration of site-specific bioengineering tools that permit custom tailorin
 g of proteins for diverse applications ranging from fluorescence nanoscopy
  to targeting posttranslational modifications.Bio:\nPhD\, Max Planck Insti
 tute for Biophysical Chemistry\, Göttingen.\nResearch Associate\, the Scr
 ipps Research Institute\, USA.\nGroup leader at EMBL since 2009.\nJoint ap
 pointment with Cell Biology and Biophysics Unit.\nEmmy Noether group leade
 r since 2010.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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