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SUMMARY:Notch: lineage specifier\, stem cell gatekeeper\, oncogene and tum
 or suppressor 
DTSTART:20111207T160000
DTSTAMP:20260407T100422Z
UID:a8e9484f5b9e99f17ce43b88c070afd6df6a5704337bd1e1b14700b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Freddy Radtke\nOver the last decades it became clear that m
 any of the signaling pathways known to be important during embryonic devel
 opment – such as Wnt\, Hh and Notch signaling - also play crucial roles 
 in self-renewing tissues. Cancer can bee seen as a disease of perturbed se
 lf-renewal in homeostatic tissues. To maintain homeostasis of a self-renew
 ing tissue (e.g. the blood\, the skin or intestine)\, processes such as se
 lf-renewal versus differentiation or apoptosis versus proliferation have t
 o be under stringent control. Disarray of these cellular processes results
  in sustained proliferation\, evading cell death\, loss of differentiation
  capacity\, invasion and metastasis - all of which are hallmarks of cancer
 . Thus\, it is not too surprising that these developmental pathways are of
 ten disheveled in cancer. In my lab we address how the deregulation of dev
 elopmental signalling cascades mechanistically contributes to cancer and w
 hether these pathways are suitable for targeted therapy. \nIn the past we 
 focused our research mostly on the evolutionarily conserved Notch pathway\
 , which regulates cellular processes such as cell fate decisions\, prolife
 ration\, differentiation and self-renewal. Over the last 5-10 years increa
 sing evidence was provided to show that Notch signalling plays an importan
 t role in multiple cancers as well as in the maintenance of cancer stem ce
 lls. Here I will discuss our contribution to understand the role of Notch 
 signalling in several self-renewing tissues\, how it may contribute to can
 cer development and progression and address whether it constitutes a valid
  target for drug development used in cancer therapy.
LOCATION:SV 1717 A
STATUS:CONFIRMED
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