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SUMMARY:Engineering Fat Cell Fate to Fight Obesity and Metabolic Diseases
DTSTART:20150710T110000
DTEND:20150710T120000
DTSTAMP:20260916T043448Z
UID:c3e379fb409acd78ea7159ee293f8b1ac538e544f6f4465380d120fb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Shingo Kajimura\nAll mammals harbor two types of adipose t
 issues that serve distinct physiological functions: white adipose tissue (
 WAT) and brown adipose tissue (BAT). WAT functions mainly in the storage o
 f excess energy\, while BAT specializes in dissipating energy in the form 
 of heat and functions as a defense against hypothermia and obesity. Since 
 adult humans possess significant amounts of active BAT depots and it’s m
 ass inversely correlates with adiposity\, BAT plays an important role in h
 uman obesity and energy homeostasis. New evidence suggests two types of th
 ermogenic adipocytes with distinct developmental and anatomical features: 
 classical brown adipocytes and beige adipocytes. Classical brown adipocyte
 s are located mainly in dedicated BAT depots of rodents and infants. Beige
  adipocytes\, on the other hand\, reside mainly in subcutaneous WAT where 
 they arise postnatally in response to certain external cues\, such as chro
 nic cold exposure and long-term treatment with PPAR-gamma agonists\, a pro
 cess often referred to as the “browning” of WAT. Importantly\, adult h
 uman BAT appears to be mainly composed of beige-like adipocytes\, making t
 his cell type an attractive therapeutic target for obesity and obesity- re
 lated diseases\, such as insulin resistance and type2 diabetes. I will rev
 iew recent progress in the molecular control of brown and beige adipocyte 
 development and discuss emerging questions\, with a special emphasis on ad
 ult human BAT.
LOCATION:SV 1717.1 http://plan.epfl.ch/?room=SV%201717.1
STATUS:CONFIRMED
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