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SUMMARY:Function and evolutionary origin of bacterial effectors subverting
  host cell signaling 
DTSTART:20150529T110000
DTEND:20150529T120000
DTSTAMP:20260408T034818Z
UID:66ed627709707be45428bda60aafa252e5aac54984cded06833cb6f2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Christoph Dehio\, Biozentrum\, University of Basel\, Switz
 erland\nPathogenic bacteria typically use dedicated protein secretion mach
 ineries to translocate bacterial effector proteins into host cells in orde
 r to manipulate cellular signaling pathways to their benefit. Pathogens of
  the genus Bartonella that cause chronic blood infections in a wide range 
 of mammals have provided insights how such trans-kingdom protein transfer 
 systems and their translocated effectors have evolved from preexisting bac
 terial structures\, and how they target specific host cellular signaling p
 rocesses. The bartonellae employ for effector translocation so called type
  IV secretion machineries that evolved from the bacterial conjugation mach
 inery. Their diverse translocated effector sets evolved from a single bact
 erial toxin-antitoxin module by multiple rounds of gene duplication and di
 versification. The effectors display multi-domain architectures that are c
 omposed of only three basic domain types that are highly versatile in func
 tion. I will use a striking example of parallel evolution to illustrate em
 ergence of convergent effectors sets in separate Bartonella lineages. More
 over\, I will provide examples of how individual effectors interfere with 
 important host cell signaling processes such as those controlling innate i
 mmune signaling\, cell death and cytoskeletal rearrangements.
LOCATION:SV 1717a
STATUS:CONFIRMED
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