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PRODID:-//Memento EPFL//
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SUMMARY:How Coronaviruses Hijack ERAD tuning for replication?
DTSTART;VALUE=DATE:20101118
DTSTAMP:20261002T012316Z
UID:bace6778977f194e3bbb4630e7bbef02493058dbedd07a1c8b9ee1eb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Maurizio Molinari\, Institute for Research in Biomedicine\, Be
 llinzona\nThe endoplasmic reticulum (ER) contains folding machineries that
  assist maturation of newly synthesized polypeptides and ER-associated deg
 radation (ERAD) machineries that remove non-native proteins. Uncontrolled 
 ERAD interferes with protein maturation by inappropriate recognition and d
 estruction of intermediates of ongoing folding programs. This is prevented
 \, at steady state\, by a series of events collectively defined as ERAD tu
 ning that insure the selective removal of ERAD regulators from the ER lume
 n in LC3-I coated vesicles\, the EDEMosomes.\nFormation of these ER-derive
 d vesicles is co-opted by positive strand RNA coronaviruses (CoVs) such as
  the severe acute respiratory syndrome (SARS)-CoV and mouse hepatitis viru
 s (MHV) for the formation of double-membrane vesicles (DMVs) to which thei
 r replication and transcription complexes are anchored.
LOCATION:
STATUS:CONFIRMED
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