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SUMMARY:Synapse Physiopathology: what have we learned from the snake presy
 naptic PLA2 neurotoxins? What else can they tell us? 
DTSTART;VALUE=DATE:20101108
DTSTAMP:20260610T093517Z
UID:7a14d374cc89bdda7ff3fe85933b6cef314c5eb18c1d0a4305581774
CATEGORIES:Conferences - Seminars
DESCRIPTION:Cesare Montecucco\, University of Padova\nSnake envenomation i
 s a major\, though forgotten\, sanitary problem in many part of the world.
  Neurotoxins and myotoxins endowed with phospholipase A2 activity are majo
 r components of snake venoms. The mechanism of degeneration of the nerve t
 erminal degeneration caused by the PLA2 snake neurotoxins will be presente
 d and shown to be dependent upon the effect of the accumulation of lysopho
 spholipids and fatty acids on the presynaptic membranes. This induces fusi
 on of ready to release synaptic vesicles and then increase of membrane per
 meability to calcium ions which causes massive neuroexocytosis. Some of th
 ese neurotoxins are then able to enter nerve terminals and inhibit mitocho
 ndria. This degeneration will be discussed in the light of the possible us
 e of these neurotoxins to study the cellular mechanisms involved in regene
 ration of peripheral nerve terminals.
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STATUS:CONFIRMED
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