BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:MicroRNA Control of Protein Expression Noise
DTSTART:20150608T110000
DTSTAMP:20260506T205357Z
UID:75d9713af702e63de75ae32afe8528dec5119d25d31fdae28761484b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Jörn Schmiedel\, Humboldt Universität and Charité Univer
 sity Hospitals\, Berlin (D)\nBIOENGINEERING SEMINARAbstract:\nMicroRNAs re
 press many genes in metazoan organisms by accelerating mRNA degradation an
 d inhibiting translation\, thereby reducing the level of protein. However\
 , microRNAs only slightly reduce the mean expression for most targeted pro
 teins\, leading to speculation about their role in the variability of prot
 ein expression\, or noise. Here we use mathematical modeling and single ce
 ll reporter assays to show that microRNAs – in conjunction with increase
 d transcription - decrease protein expression noise for lowly expressed ge
 nes\, but increase noise for highly expressed genes.  Genes that are regu
 lated by multiple microRNAs show more pronounced noise reduction. We estim
 ate that hundreds of (lowly expressed) genes in mouse embryonic stem cells
  have reduced noise due to substantial microRNA regulation. Our findings t
 herefore suggest that microRNAs confer precision to protein expression and
  thus offer plausible explanations for the commonly observed combinatorial
  targeting of endogenous genes by multiple microRNAs as well as the prefer
 ential targeting of lowly expressed genes.Bio:\nOct 2013–present\n   
  Visiting Researcher\n    Hubrecht Institute · Prof. Alexander van Oud
 enaarden\n    Utrecht\, The Netherlands\nApr 2012–Sep 2013\n    Vi
 siting Researcher\n    Massachusetts Institute of Technology · Departm
 ent of Biology · Prof. Alexander van Oudenaarden\n    Cambridge\, MA\,
  USA\nSep 2010–present\n    Visiting Researcher\n    Harvard Medic
 al School · Department of Systems Biology · Dr. Debora Marks\n    Bos
 ton\, MA\, USA\nMay 2010–present\n    PhD Student\n    Charité Un
 iversitätsmedizin Berlin · Institute of Theoretical Biology · Prof. Nil
 s Blüthgen\n    Berlin\, Germany
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR