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SUMMARY:Inhibitory Activities of Short Linear Motifs Underlie Hox Interact
 ome Specificity in vivo
DTSTART:20150618T140000
DTSTAMP:20260428T132544Z
UID:a5ca86a04dc1feacfddc1db5746d3ee59394028ae3040a8d76405545
CATEGORIES:Conferences - Seminars
DESCRIPTION:Samir Merabet\, Ph.D.\, ENS\, Lyon (F)\nBIOENGINEERING SEMINAR
 Abstract:\nHox proteins are well-established developmental regulators that
  coordinate cell fate and morphogenesis throughout embryogenesis. In contr
 ast\, our knowledge of their specific molecular modes of action is limited
  to the interaction with few cofactors. Here we show that Hox proteins are
  able to interact with a wide range of transcription factors in the live D
 rosophila embryo. In this context\, specificity relies on a versatile usag
 e of conserved short linear motifs (SLiMs)\, which\, surprisingly\, often 
 restrains the interaction potential of Hox proteins. This novel buffering 
 activity of SLiMs was observed in different tissues and found in Hox prote
 ins from cnidarian to mouse species. Although our results remain to be fun
 ctionally validated\, they challenge the traditional role assigned to SLiM
 s and provide an alternative concept to explain how Hox interactome specif
 icity could be achieved during the embryonic development.Bio:\n    Curr
 ent: Institut de Génomique Fonctionnelle de Lyon (IGFL)\, Lyon\, France\n
     Affolter Lab\, Universität Basel\, Switzerland\n    Centre nati
 onal de la recherche scientifique\, Paris\, France\n    Université Aix
 -Marseille
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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