BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:An interplay between 14-3-3 and the Rab11 binding protein Rip11 is
  necessary for the completion of cytokinesis
DTSTART:20150701T140000
DTEND:20150701T150000
DTSTAMP:20260510T164637Z
UID:89d233ea679dc6bccaa3af96143eb7911c676905039b26a6ac6b4b1f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Emery Gregory - Institute for Research in Immunology and Cance
 r\, Canada\nThe 14-3-3 family of phospho-Ser/Thr binding proteins orchestr
 ates a complex network of molecular interactions involved in various biolo
 gical functions such as cell growth\, cell cycle progression\, apoptosis a
 nd differentiation. By using an affinity-based chromatography combined wit
 h tandem mass spectrometry\, we have identified numerous new 14-3-3 bindin
 g proteins\, including the class I Rab11-FIPs which are known as effectors
  of the small GTPase Rab11. Interestingly\, we found that the interaction 
 between Rip11\, the sole class I Rab11-FIP in Drosophila\, and 14-3-3 is n
 ecessary for completion of cytokinesis in S2 cells. Indeed\, we found that
  Rip11 regulates the composition of the midbody\, the intercellular struct
 ure necessary to perform the abscission which will eventually separate the
  two daughter cells. Hence\, our work reveals a new role for both 14-3-3 a
 nd Rip11 during cytokinesis and partially explain the recruitment of key r
 egulators of cytokinesis to the midbody.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR