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SUMMARY:The peptidoglycan as a signalling molecule in the host
DTSTART:20150707T170000
DTEND:20150707T180000
DTSTAMP:20260925T122220Z
UID:baec4a1d13fe6bdd4c1554d72cb8bc3f82695d8833c0b27e9f839fcf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ivo Boneca - Institut Pasteur - Unité Biologie et génétique
  de la paroi bactérienne - Paris - France\nThe intestinal bacterial flora
  plays a critical role in human health and disease\; host recognition of b
 acterial components\, such as peptidoglycan (PGN)\, triggers maturation of
  host physiology and modulates immune homeostasis. PGN is sensed by intrac
 ellular NOD-like receptors NOD1 and NOD2\, and can promote or suppress the
  gut inflammatory response. PGN released by gut microbiota can cross the i
 ntestinal epithelial barrier and disseminate systemically in the host to m
 ediate immune homeostasis\, however PGN transcytosis pathways and the subs
 equent interactions with the host innate immune system upon reaching the i
 mmunologically rich niche of the intestinal lamina propria have not been c
 haracterised.  Using fluorescent PGN molecules as probes to trace PGN upt
 ake in the mouse gut\, we found that PGN accumulates in lamina propria eos
 inophils – a completely unanticipated role for these granulocytes. This 
 observation is compelling\, as in mammals the gut is the major tissue nich
 e for eosinophils\, yet the reason for their abundance in the gut at the s
 teady state is largely unknown. We show that transcytosis of the epithelia
 l barrier and uptake of PGN by eosinophils is an extremely rapid processes
 . We then used quantitative multi-analyte profiling to assess the host res
 ponse to orally administered PGN in an axenic (germ-free) mouse model. We 
 found that key eosinophil and monocyte recruitment factors are induced in 
 response to PGN. Our data therefore indicates a prominent role for eosinop
 hils in regulation of gut immune homeostasis in response to PGN. Our conti
 nuing work aims to decipher how PGN signalling modulates host gut physiolo
 gy and the role of eosinophils in this context.
LOCATION:AI 1153  https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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