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SUMMARY:Novel Applications of Human Liver Chimeric Mice
DTSTART:20150807T110000
DTEND:20150807T120000
DTSTAMP:20260930T210024Z
UID:47be95207190f46f1b207438d0825e9031044aa45aac47d816733e79
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Karl-Dimiter Bissig\, Baylor College of Medicine\nSince 
 the first description of human liver chimeric mice\, there have been many 
 applications of this versatile small animal model.  In this talk\, I will
  present two new applications of human liver chimeric mice. By transplanti
 ng diseased human hepatocytes from a metabolic disease patient (familial h
 ypercholesterolemia)\, we have managed to induce human disease in murine h
 osts and thereby have established the first xenograft model for human meta
 bolic liver disease. Further\, we were able to rescue the disease phenotyp
 e with an experimental gene therapy. I will also introduce a new liver can
 cer model\, which faithfully mimics human disease and is in many ways supe
 rior to current cancer models.
LOCATION:AI1153 http://plan.epfl.ch/
STATUS:CONFIRMED
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