BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Mycolactone - a Mycobacterium ulcerans lipid dysregulating host ce
 ll dynamics
DTSTART:20100322T133000
DTSTAMP:20260921T013843Z
UID:71a2525fbc8bf63d474c403a58d937adc5a6a3ba62013e96b88a9598
CATEGORIES:Conferences - Seminars
DESCRIPTION:Caroline Demangel\, Institut Pasteur\nMycobacterium ulcerans i
 s unique among human pathogens in its capacity to produce mycolactones\, a
  family of macrocyclic polyketides required for virulence. Mycolactones ar
 e diffusible molecules penetrating target cells passively and causing thei
 r death by an apoptosis-dependent mechanism. Inactive on bacteria\, their 
 biological activity appears restricted to protozoa\, insect and vertebrate
  cells. In immune cells\, mycolactones display additional and original pro
 perties\, resulting in decreased responsiveness to stimulation and impaire
 d trafficking capacity. Our recent data suggest that mycolactones cause th
 ese various alterations by interfering with the eukaryotic cytoskeletal ma
 chinery\, through an interaction with key regulators of actin polymerisati
 on that are essential for many immune cell functions. Implications for the
  neutralization of mycolactones and their potential therapeutic uses will 
 be discussed.
LOCATION:SV 1717A
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR