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SUMMARY:Advanced Genetic Systems to Improve Molecular Diagnostics and Targ
 eted Therapies
DTSTART:20150908T130000
DTSTAMP:20260528T120305Z
UID:071c56ae51fc1679b21fbac80f4951594f05880a8c8d1df95205bd42
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. med. Dieter Saur\, II. Medizinische Klinik und Polik
 linik Klinikum rechts der Isar der TU München\, Germany\nMaintenance and 
 drug resistance of gastrointestinal cancer subtypes depends on cancer cell
  intrinsic mechanisms and a stroma that supports tumor growth. Mouse model
 s have provided important insights into the evolution of these cancer type
 s\, but there are no models that allow secondary genetic manipulation of a
 utochthonous tumors\, the tumor microenvironment or the metastatic host ni
 che once the tumor has formed. We have generated inducible dual-recombinas
 e based cancer models that permit spatial and temporal control of gene exp
 ression. This tool provides unparalleled access to the native biology of c
 ancer cells and their hosting stroma\, and rigorous genetic validation of 
 candidate therapeutic targets. We performed tumor cell-autonomous and non-
 autonomous targeting\, uncovered hallmarks of human multistep carcinogenes
 is\, validated genetic tumor therapy\, and showed that mast cells in the t
 umor microenvironment\, which had been thought to be key oncogenic players
 \, are in fact dispensable for tumor formation in the pancreas.
LOCATION:AI 1.153 http://plan.epfl.ch/?zoom=19&recenter_y=5864127.68295&re
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STATUS:CONFIRMED
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