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SUMMARY:Regulation of Intestinal Immune Homeostasis in Mouse and Man
DTSTART:20150827T133000
DTSTAMP:20260916T055259Z
UID:85e902c934a489ad999e2f37a6c05e266a46df39c31238b2a853c16e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Arthur Mortha\, Center for Science and Medicine at the Mount S
 inai Medical Center Department of Oncological Sciences\, New York\nThe gut
  is the body’s largest mucosal surface and serves as entry port for nutr
 ients\, water\, minerals and vitamins. It harbors a universe of microbial 
 species known as the intestinal commensal microflora. Preserving proper in
 testinal homeostasis is the key to ensure optimal nutrient absorption. Exp
 osures to microbial molecules and food-borne antigens cause permanently ac
 tivate the gut-residing immune system\, even in a healthy organism. Overri
 ding activation of the intestinal immune system by luminal antigens is com
 monly kept in check by potent immune-suppressive cells. The suppression of
  the immune activation is an essential cellular system that prevents immun
 e-mediated damage of the gut. Permanent tissue damage\, nutrient-intoleran
 ce\, changes in microbial composition and function are only a few of the c
 onsequences resulting from a failure in suppression of the destructive act
 ivated gut immune system.\nWe have identified a cellular and molecular net
 work that promotes the generation of immune-suppressive cells\, supporting
  the tolerance to food-antigens. Our results define intestinal\, microflor
 a-derived signals as key initiator of this network. Recognition and interp
 retation of the intestinal microflora by innate immune cells thereafter di
 ctates the phenotype of effector cells that facilitate the generation of e
 ssential intestinal immune-suppression. The occurrence of chronic intestin
 al inflammation and defects in tolerance to food-antigens strongly associa
 te with genetic and idiopathic alterations of this network in mice and man
 \, further highlighting its relevance in the maintenance of intestinal fun
 ctionality. Thus\, our network provides a critical mechanism through which
  the gut microbiota supports intestinal immune-suppression and protects im
 munologic tolerance to food and preserves intestinal functionality.
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STATUS:CONFIRMED
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