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SUMMARY:Analysis of tumor microenvironment interactions from an engineerin
 g perspective
DTSTART:20151109T131500
DTEND:20151109T141500
DTSTAMP:20260510T164709Z
UID:0030188f7ee17ee39b2233d80a2188cae6f93fcc52933f66aa219e99
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Claudia Fischbach-Teschl\, Nancy E. and Peter C. Meinig 
 School of Biomedical Engineering\, Cornell University\nMicroenvironmental 
 conditions contribute to the pathogenesis of cancer\, and aberrant extrace
 llular matrix (ECM) remodeling plays a key role in this process. However\,
  our understanding of the specific mechanisms by which the ECM promotes ca
 ncer is relatively limited. Our lab focuses on the integration of material
 s science\, tissue engineering\, and cancer biology approaches to test the
  role of ECM biological and physical properties in cancer initiation and p
 rogression. More specifically\, we characterize the effect of tumors on EC
 M composition\, structure\, and mechanics and investigate the relevance of
  these changes to tumor cell behavior both in vitro and in vivo. Additiona
 lly\, we are evaluating whether obesity\, a condition commonly associated 
 with an increased risk and worse clinical prognosis for cancer\, may promo
 te tumorigenesis by mimicking tumor-like ECM dynamics.\nSeo BR\, DelNero P
 \, Fischbach C\, In vitro models of tumor vessels and matrix: Engineering 
 approaches to investigate transport limitations and drug delivery in cance
 r. Advanced Drug Delivery Reviews\, 2014 Apr 20\;69-70C:205-216.\nChandler
 \, E.M.\, Seo\, Bo Ri\, Califano\, J.P.\, Andresen Eguiluz\, R.C.\, Lee\, 
 J.S.\, Yoon\, C.J.\, Tims\, D.T.\, Wang\, J.X.\, Cheng\, L.\, Mohanan\, S.
 \, Buckley\, M.R.\, Cohen\, I.\, Nikitin\, A.Y.\, Williams\, R.M.\, Gourdo
 n\, D.\, Reinhart-King\, C.A.\, Fischbach\, C.\, Implanted adipose progeni
 tor cells as physicochemical regulators of breast cancer\, Proc Natl Acad 
 Sci U S A 2012 Jun 19\;109(25):9786-91.\nBio: Claudia Fischbach-Teschl is 
 an Associate Professor of Biomedical Engineering at Cornell University. Sh
 e received her Ph.D. in Pharmaceutical Technology from the University of R
 egensburg\, Germany\, and holds an M.S. in Pharmacy from the Ludwigs-Maxim
 ilians-University\, Munich\, Germany. She conducted her postdoctoral work 
 at Harvard University in the Division of Engineering and Applied Sciences 
 and joined the faculty of Cornell in 2007. Her research broadly focuses on
  utilizing engineering tools and strategies to gain a better understanding
  of cancer development\, progression\, and therapy resistance with a parti
 cular focus on adipose stroma contributions to breast cancer\, bone metast
 asis and tumor angiogenesis. She has received multiple awards for her work
  including an AAOS / ORS Molecular Biology and Therapeutics in Musculoskel
 etal Oncology Young Investigator Award and a Humboldt Research Fellowship 
 for Experienced Researchers from Germany. Furthermore\, she is an editoria
 l board member of various journals including the new ACS journal Biomateri
 als Science and Engineering.
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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