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SUMMARY:STEPS: REACTION-DIFFUSION SIMULATION IN COMPLEX 3D GEOMETRIES
DTSTART:20100204T143000
DTSTAMP:20260407T010257Z
UID:b82b2c7b60013b7767f14c8398ec3fa7ed19d885e1e3d113a4b6b098
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Erik De Schutter\, Computational Neuroscience Unit\, Oki
 nawa\, Japan\, Theoretical Neurobiology\, University of Antwerp\, Belgi \n
 I will give an overview of the STEPS software and present preliminary data
  on using STEPS to model the stochastic induction of cerebellar long-term 
 depression (LTD). STEPS (STochastic Engine for Pathway Simulation) is a pl
 atform for simulation of signalling pathways where the spatial organizatio
 n and morphology of the cell can be represented by complex 3D tetrahedral 
 meshes. Our core algorithm is based on Gillespie’s Direct Method extende
 d for membrane reactions and diffusive fluxes between tetrahedral voxels. 
 I'll demonstrate our use of STEPS to simulate anomalous diffusion in Purki
 nje cell spiny dendrites and to simulate the signaling pathways involved i
 n the induction of LTD at the parallel fiber to Purkinje cell synapse.
LOCATION:AI 1-153
STATUS:CONFIRMED
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