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SUMMARY:Anticancer metallocomplexes with non-classical modes of activity
DTSTART:20150903T160000
DTEND:20150903T170000
DTSTAMP:20260407T055245Z
UID:68b44bd480f94716ea7d27116c74aba535d108f8933e6b67c3f74d5e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ang Wee Han\, National University of Singapore\nPlatinum
 -based anticancer drugs\, cisplatin\, carboplatin and oxaliplatin\, are so
 me of the most effective chemotherapies used in clinic. Their cytotoxic ac
 tivity against cancer stems from a combination of processes including cell
  entry\, drug activation\, DNA-binding and transcription inhibition\, resu
 lting in apoptotic cell death. Due to limitations in platinum-based therap
 y arising from toxicity\, high side-effects and incidence of drug resistan
 ce\, there have been a renewed interest in studying other metallocomplexes
  as alternatives and to revisiting some of the earlier assumptions. There 
 is evidence that for these cytotoxics\, at least part of the observed clin
 ical therapeutic efficacy of these agents actually hinges on its “off-ta
 rget” immunostimulating mechanisms. Because cytotoxic chemotherapeutic d
 rugs have been thought of as immunosuppressive\, they have been generally 
 discounted as potential immunotherapeutic agents. Our preliminary work ide
 ntifying platinum-based complexes that induce immunogenic cell death\, a c
 ell death mechanism that specifically elicit an immunological response\, w
 ill be discussed. I will also report a rationally-designed platinum(IV)-pe
 ptide conjugate that activates peripheral blood mononuclear cells towards 
 cancer cells via the FPR-1/2  pathway. These efforts pave the way for pla
 tinum compounds as immuno-chemotherapeutic agents for cancer therapy. Alon
 g the theme of non-classical metallodrugs\, I report a combinatorial metho
 d of preparing ruthenium-arene complexes for drug discovery and its applic
 ation toward developing metallocomplexes with different modes of action co
 mpared to classical platinum drugs.
LOCATION:BCH 5310 https://plan.epfl.ch/?room==BCH%205310
STATUS:CONFIRMED
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