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SUMMARY:Antibodies enhance infection of liver sinusoidal endothelial cells
  in a mouse model of severe dengue disease
DTSTART:20100201T121500
DTSTAMP:20260922T023515Z
UID:67e3b125943a6d89ba94a34fbb181fe9491d498d470b054543525126
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Raphael Zellweger\, La Jolla Institute for Allergy and Immu
 nology\, California\nDengue virus (DENV) causes disease ranging from dengu
 e fever (DF)\, a self-limited febrile illness\, to the potentially lethal 
 dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS). DHF/DSS usua
 lly occurs in patients who have acquired DENV-reactive antibodies prior to
  infection\, either from a previous infection with a heterologous DENV ser
 otype or from an immune mother. Hence\, it has been hypothesized that subn
 eutralizing levels of antibodies exacerbate disease\, a phenomenon termed 
 antibody-dependent enhancement (ADE). However\, given the lack of suitable
  animal models for DENV infection\, the mechanism of ADE and its contribut
 ion to pathology remain elusive. Here\, we demonstrate in mice that DENV-s
 pecific antibodies can sufficiently increase severity of disease so that a
  mostly non-lethal illness becomes a fatal disease resembling human DHF/DS
 S. Antibodies promote massive infection of liver sinusoidal endothelial ce
 lls (LSECs)\, resulting in increased systemic levels of virus. Thus\, a su
 bprotective humoral response may\, under some circumstances\, have patholo
 gical consequences
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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