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SUMMARY:Mitochondrial Proteins\, Pathways\, and Pathogenesis
DTSTART:20151007T140000
DTEND:20151007T150000
DTSTAMP:20260407T020335Z
UID:f65c670d775ed444757f49201b2abedff6831e8647bfee934ccc16ad
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David J. Pagliarini\, Morgridge Institute for Research\,
  University of Wisconsin\, Madison\, WI (USA)\nSEMINAR of the LAUSANNE INT
 EGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)Abstract:\nMitochondrial
  dysfunction is associated with a spectrum of rare inborn errors of metabo
 lism and an increasing number of common diseases\, including Parkinson’s
 \, Alzheimer’s\, various cancers and type 2 diabetes. However\, the natu
 re and cause of this dysfunction is quite often confounding or unclear. Ce
 ntral to this problem is the recent realization that mitochondria are much
  more complex than once thought and possess hundreds of proteins with no k
 nown biochemical functions. Elucidating the biochemical functions of these
  proteins has become a major bottleneck in understanding basic mitochondri
 al biology and the pathophysiology of mitochondria-related disorders. The 
 long-term significance of my research program is to widen this biomedical 
 bottleneck by accelerating the functional annotation of key disease-relate
 d “orphan” mitochondrial proteins (OMPs)\, thereby taking an important
  first step toward rational therapeutic design for many mitochondrial dise
 ases. We do so by first designing large-scale mass spectrometry and comput
 ational analyses designed to make initial connections between OMPs and kno
 wn mitochondrial pathways and processes\, and then employing mechanistic a
 nd structural approaches to define the functions of select OMPs at biochem
 ical depth.Bio:\nDavid Pagliarini joined University of Wisconsin-Madison a
 s an assistant professor of biochemistry in 2009\, and was appointed assoc
 iate professor of Biochemistry in 2015. He received his PhD in 2005 in bio
 medical sciences from the University of California-San Diego and did his p
 ostdoctoral training at Harvard Medical School until 2009. He is Director 
 and Nielsen Chair of Metabolism at the Morgridge Institute for Research.On
  the web:Pagliarini LabMorgridge Metabolism
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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