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SUMMARY:Flexible microfabricated electrode arrays for Deep Brain Stimulati
 on
DTSTART:20151022T161500
DTSTAMP:20260509T054559Z
UID:5def5e35911991e3672873d3351bccfa9b7f23b98127e39d1fb67440
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michel Decré\, Medtronic Eidhoven Design Center \nDeep brain
  stimulation (DBS) is approved worldwide for the treatment of Parkinson’
 s disease (PD)\, essential tremor\, dystonia\, obsessive-compulsive disord
 er (OCD) and more recently epilepsy\, while other neurological and psychia
 tric disorders are under investigation. Starting in 2005 at Philips Resear
 ch\, we developed an innovative\, microfabricated high-resolution DBS impl
 ant with the capacity to steer electrical pulses away from areas of the br
 ain that can produce undesirable side-effects. The project was spun off as
  Sapiens in 2011\, and finally acquired by Medtronic in 2014.\nWe will cov
 er the key system architecture\, engineering choices\, and technology inno
 vation elements of the steering DBS system. We will of course devote speci
 al attention to the thin-film manufacturing technology\, the array connect
 ivity\, manufacturability\, and some testing challenges. We will then disc
 uss the intra-operative FAME (First–Acute-in-Man-Evaluation) pilot study
  performed at the Department of Neurosurgery \, Academic Medical Center (A
 MC)\, Amsterdam\, that was the first clinical investigation of Sapiens’ 
 new high-resolution SureStim™ lead.\nFinally\, we will also include cons
 iderations of the innovation process\, from initial invention\, through sp
 in-off\, to “exit” as an acquisition.\nBio: Michel Decré\, PhD\, is f
 ounder and chief technology officer of Sapiens. He initiated and led the w
 ork on deep brain stimulation at Philips Research from 2006-2011 with a mu
 ltidisciplinary team from Philips Research\, Philips AppTech\, and Philips
  MiPlaza. He successfully led the joint development project with Neuronexu
 s Technologies Inc. in Ann Arbor\, MI from 2008-2010.\nDecré is renowned 
 for his work on thin film technology\, which is at the heart of Sapiens’
  implant and co-invented numerous filed patents and applications in this f
 ield. He is a visiting professor at Leeds University. He was a member of t
 he Dutch Organisation for Scientific Research (NWO-FOM) “Brain and Cogni
 tion” Scouting Commission\, and of the technology watch foundation STT 
 “Brain Visions” Study Group. Decré coordinated national and European 
 Commission (EC)-subsidized projects (NAPS\, Brainmimic) and was industrial
  coordinator of EC-funded Neuroprobes. The wave-printing technology he co-
 invented and developed with his Philips team from 2001-2005 was successful
 ly transferred to Suess-MicroTech\, Germany (SCIL technology\, “Substrat
 e Conformal Imprint Lithography”).
LOCATION:EPFL\, CO2
STATUS:CONFIRMED
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