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SUMMARY:Novel strategies to design microbial production strains - ready to
  be scaled up
DTSTART:20151016T161500
DTSTAMP:20260506T195254Z
UID:9087bbedaae2482b6c64920924c185674f7f7152d5a64f8cfe8e8bec
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Anton Glieder\, Technische Universität Graz\, Austria\n
 Anton Glieder's main interests are in protein engineering\, yeast-based  
 protein expression and whole-cell catalysis systems\, directed  evolution
 \, industrial biocatalysis\, yeast metabolic engineering and  synthetic b
 iology. His current interests specifically focus on two main topics:\n(i) 
 the engineering of proteins towards improved fitness  for industrial or t
 herapeutic application\, and\n(ii) using systems  biology and metabolic e
 ngineering to improve the physiology of  expression strains to enhance pr
 oduction of proteins as well as  primary and secondary metabolites.\nIn a
 ddition to the  application-oriented engineering of proteins\, evolutiona
 ry engineering  techniques are attractive for clarifying the structure-fu
 nction  relationship of enzymes and their cellular functions.\nLaboratory
  Techniques:\nProtein engineering methods are used routinely in A. Glieder
 's  laboratory for rational design as well as for the random generation o
 f  large libraries of individual variants of industrial enzymes from  pr
 okaryotic and eukaryotic cells. Enzyme assays in high-throughput formats a
 re well established for many different enzyme families\,  allowing qualit
 ative analysis on a colony level as well as paralleled  kinetic analysis 
 of large numbers of enzyme variants. High-throughput  LC-MS based analyti
 cs was established for screenings using unmodified  target substrates ins
 tead of surrogate substrates. Special proprietary  tools for efficient pr
 otein expression and engineering employing  Pichia pastoris were develope
 d.\nBio: Anton Glieder studied Chemistry and Biochemistry at the Universit
 y of  Vienna. After receiving his diploma\, he moved to Graz and complete
 d  his PhD in microbiology at the University of Graz. From 1993 to 1997\,
   he was a postdoctoral fellow at the special research programme  Biocat
 alysis at the Graz University of Technology. Following 3 years  of indust
 rial experience\, he started his academic career as an  assistant profess
 or at the Graz University of Technology\, and after a  year\, as a visiti
 ng scientist in Frances H. Arnold´s lab at Caltech.\nHe joined the Rese
 arch Centre Applied Biocatalysis (A-B) as a project  leader and key resea
 rcher in 2002. In 2003\, Anton Glieder became  associate professor at the
  Institute of Molecular Biotechnology at the  Graz University of Technolo
 gy\, obtaining the first Dr. W. Houska award  in 2006. In 2008\, Anton Gl
 ieder became scientific director of the ACIB  initiative\, and in 2009\, 
 he also became the scientific director of the  Research Centre Applied Bi
 ocatalysis (Angewandte Biokatalyse GmbH). As  of November 1\, 2010\, he w
 as part of the Executive Board of Directors  (Scientific Director . CEO &
  CSO) of the Austrian Centre of Industrial  Biotechnology (ACIB GmbH)\, w
 here he remained until March 2014.\nCurrently\, he is pursuing his researc
 h as a professor at the Graz  University of Technology and an ACIB key sc
 ientist.
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STATUS:CONFIRMED
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