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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Poised Transcription Complexes In Epigenetics And Genome Function
DTSTART:20091216T163000
DTSTAMP:20260511T204837Z
UID:a4f629172bf8d54db74f9ba082b95537957e1bdb3bd52d86a29ae929
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Ana Pombo\nOur main aim is to understand the molecular and 
 structural processes that regulate gene expression in the context of the i
 nterphase nucleus. We are investigating the relationship between genome ar
 chitecture and gene expression in embryonic stem (ES) cells\, differentiat
 ed systems and in neurodegeneration. We have developed high-resolution ima
 ging methods for the visualisation of spatial relationships within the nuc
 leus (e.g. cryo-FISH)\, and aim to understand the contribution of nuclear 
 positioning on gene expression. Using chromatin immunoprecipitation (ChIP)
 \, we have shown that poised RNA polymerase II complexes are bound in ES c
 ells at inactive\, ‘bivalent’ genes that are important for early ES ce
 ll differentiation. We are currently studying their activity and regulatio
 n. We have identified poised transcription factories and are investigating
  their association with inducible genes.
LOCATION:SV 1717A
STATUS:CONFIRMED
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