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SUMMARY:Reprogramming Membrane Protein Function by Design
DTSTART:20151116T121500
DTSTAMP:20260408T184900Z
UID:8ce75ecefe78c806aa4f8011e5d4a762ca0debe9546391dee297aeb1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Patrick Barth\, Baylor College of Medicine\, Houston\, T
 X (USA)\nBIOENGINEERING SEMINAR(sandwiches served)NB: video broadcast to C
 HUV and Ludwig Institute for Cancer Research at ÉpalingesAbstract:\nCommu
 nication and transport across lipid membranes control a large variety of c
 ellular processes but remain poorly understood\, largely because membrane 
 proteins are difficult to study experimentally. The scarcity of high-resol
 ution membrane protein structures and mechanistic insights hinder the deve
 lopment of effective therapeutics\, with membrane proteins estimated to re
 present around 60% of possible cellular drug targets. To address these cha
 llenges\, we have recently developed an ensemble of integrated computation
 al/experimental approaches to accurately model and design membrane protein
  structures and functions. With our novel methods\, we can (1) successfull
 y predict the functional consequences of membrane protein sequence variati
 ons\, (2) uncover novel molecular determinants of membrane protein structu
 re and function\, and (3) rationally design membrane receptors with novel 
 biophysical and signaling properties. We leverage these combinatorial appr
 oaches to engineer biosensors\, as well as reprogram and create novel sign
 aling pathways for applications in synthetic\, systems biology and persona
 lized medicine\, including immunotherapeutic interventions.Bio:\nEducation
 :\n   PhD from University of Paris / CEA Saclay\, Paris\, France\nPositi
 ons:\n   Assistant Professor of Pharmacology\, Baylor College of Medicin
 e\, Houston\, TX\, USA
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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