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SUMMARY:Mechanisms and Dynamics of the Coupling Between the Circadian Cloc
 k and the Cell Cycle Oscillators 
DTSTART:20151214T111500
DTSTAMP:20260929T043750Z
UID:d72a17e35fec6438388a277f639f0f8a781c1e7e7dcd248e4150d9ff
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Franck Delaunay\, University Nice Sophia Antipolis\, Nic
 e (F)\nBIOENGINEERING SEMINARAbstract:\nDaily synchronous rhythms of cell 
 division at the tissue or organism level are observed in many species and 
 suggest that the circadian clock and cell cycle oscillators are coupled. D
 espite known molecular links\, little is known regarding the dynamics of t
 his coupling and how the temporal organisation of cell division at the sin
 gle cell level produces the daily rhythm at the tissue level. Using multis
 pectral imaging of single live cells\, computational methods and mathemati
 cal modelling we have addressed this question in proliferating mouse fibro
 blasts. This approach revealed that in unsynchronized cells\, the cell cyc
 le and circadian clock robustly phase-lock each other in a 1:1 fashion so 
 that in an expanding cell population the two oscillators oscillate in a sy
 nchronized way with a common frequency. Pharmacological synchronization of
  cellular clocks reveals additional phase-locked clock states. The tempora
 l coordination of cell division by phase-locking to the clock at a single 
 cell level has significant implications because disordered circadian funct
 ion is increasingly being linked to the pathogenesis of many diseases incl
 uding cancer.Bio:\nCurrent position:\nProfessor of animal physiology at In
 stitute of Biology Valrose\, CNRS\, INSERM\, University Nice Sophia Antipo
 lis\, Nice (F)\nBackground:\nMolecular endocrinology\nEducation:\nUniversi
 té de Rennes (F)\nKarolinska Institute\, Stockholm (SE)\nÉcole Normale s
 upérieure\, Lyon (F)
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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