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SUMMARY:Plant receptor kinase-mediated innate immunity
DTSTART:20160202T121500
DTSTAMP:20260916T050023Z
UID:7acdf74f28bcb8b2ac5b97741267d6aa59dec2ab319de5153d9b1ee3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Cyril Zipfel\nAs in animals\, the first layer of plant i
 nnate immune recognition relies on the perception of pathogen-associated m
 olecular patterns by pattern recognition receptors (PRRs). In plants\, all
  known PRRs are cell surface ligand-binding receptor kinases or receptor-l
 ike proteins (which unlike receptor kinases lack an intracellular kinase d
 omain\; hence\, requiring heteromeric complex formation with accessory rec
 eptor kinases). It is now becoming increasingly clear that plant PRRs are 
 part of multimeric protein complexes at the plasma membrane\, in a manner 
 similar to the Myddosome for mammalian Toll-like receptors. In my presenta
 tion\, I will present our recent work that shed light on the molecular mec
 hanisms that control the activation of plant PRR complexes and of downstre
 am cell-autonomous immune responses. In addition\, I will illustrate how t
 he use of plant PRRs represents a promising biotechnological tool to engin
 eer disease resistance in crops.\nSelected references:\nHolton et al.\, PL
 oS Pathog.\, 1(1): e1004602.\nMonaghan et al. (2014) Cell Host Microbe\, 1
 6(5): 605-615.\nSegonzac et al. (2014) EMBO J.\, 33(18): 2069-2079.\nZipfe
 l (2014) Trends Immunol.\, 35(7): 345-351.\nMacho & Zipfel C (2014) Mol. C
 ell\, 54(2): 263-272.\nKadota et al. (2014) Mol. Cell\, 54 (1): 43-55.\nMa
 cho et al. (2014) Science\, 343 (6178): 1509-1512.\nSun et al. (2013) Scie
 nce\, 342 (6158): 624-628.\nLacombe et al. (2010) Nature Biotech.\, 28(4):
  365-369.
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STATUS:CONFIRMED
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