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SUMMARY:A Perfect Match: How Metabolism Supports Cancer Cell Proliferation
  and Survival
DTSTART:20160118T141500
DTSTAMP:20260427T215225Z
UID:fe21e10b591182879cb0248613f3e5cd9481685988ee9e5059b6776f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sarah-Maria Fendt\, VIB Vesalius Research Center\, KU Le
 uven (B)\nBIOENGINEERING SEMINARAbstract:\nCellular metabolism is a networ
 k of biochemical reactions that converts nutrients taken up from the micro
 environment into metabolic products such as energy\, antioxidants\, or bio
 mass precursors. Consequently\, cellular metabolism supports survival and 
 proliferation of cells. During an oncogenic transformation normal metaboli
 sm is rewired to support the specific requirements of transformed cells. T
 hese requirements of transformed cells vary dependent on the cancer progre
 ssion state and thus cancer cells rewire their metabolism accordingly. We 
 are investigating how transformed cells rewire their metabolism to support
  primary tumor proliferation\, but also metastatic cancer cell survival an
 d colonization. Using metabolomics and 13C tracer analysis we have identif
 ied that metabolic rewiring in proliferating cells is needed to support nu
 cleotide production\, while it supports energy production in metastasizing
  cancer cells. In conclusion\, identifying how cellular metabolism support
 s transformed cells during cancer progression allows us to advance metabol
 ic drugs beyond their use as anti-proliferating agents to drugs that can i
 nhibit the survival of metastatic cancer cells.Bio:\nPhD: ETH Zurich\, Ins
 titute of Molecular Systems Biology\, 2009\nPostdoctoral Fellow: Harvard M
 edical School\, Boston\, 2010\nPostdoctoral Fellow: Massachusetts Institut
 e of Technology\, Cambridge\, 2011-2012\nVIB Group leader since 2013
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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