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SUMMARY:« pH-sensing receptors »
DTSTART:20091023T113000
DTSTAMP:20260503T131638Z
UID:bbf9b18934574e3d9b0e8bf71ba84666ccaeb8b890a28965639aea5c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Klaus Seuwen\, Principal Research Investigator\, Novartis\n
 G protein-coupled receptors (GPCRs) constitute the largest gene family in 
 mammalian genomes. These receptors and there ligands are involved in the r
 egulation of virtually all physiological processes. The receptors GPR4 and
  OGR1 (ovarian cancer G protein-coupled receptor 1\; GPR68) were identifie
 d during efforts to clone new members of the GPCR family. T cell death-ass
 ociated gene 8 (TDAG8\, GPR65) emerged as a gene up-regulated during gluco
 corticoid treatment of T cells. The three receptors show significant simil
 arity at the amino acid level. \nActivating ligands for these receptors re
 mained unknown for several years\, until lipid messengers were described a
 s agonists. These findings are today in part withdrawn\, and we demonstrat
 ed activation of OGR1 and GPR4 by acidic extracellular pH. Other laborator
 ies reported a similar type of regulation for TDAG8. \nThe physiological r
 oles of the pH-sensing receptors are being elucidated using genetically mo
 dified animal models. First data become available from studies with OGR1\,
  GPR4 and TDAG8 knockout animals\, and suggest an implication of these rec
 eptors in bone & kidney physiology\, respiration\, endothelial function an
 d immunology. 
LOCATION:ROOM : AI 1153
STATUS:CONFIRMED
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