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SUMMARY:The DNA Damage Response: Chromatin and Cancer
DTSTART:20160127T160000
DTEND:20160127T180000
DTSTAMP:20260505T015323Z
UID:ddebc1cc2e51651620f82aaa321b43d7b774febc0a415a824d7f73dd
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kyle Miller\nUT Austin\, USA\nEndogenous and exogenous f
 actors are constantly threatening the integrity of our genomes. Cells resp
 ond to genetic insults by mounting a complex signaling system collectively
  termed the DNA damage response (DDR)\, a network of proteins that functio
 n to detect\, signal and repair damaged DNA. Many DDR activities take plac
 e within chromatin\, the protein-DNA complexes that organizes the eukaryot
 ic nuclear genome and regulates both epigenome and genome functions. The s
 tructure and function of chromatin are regulated by histone modifications 
 and chromatin modifying enzymes\, which can markedly influence the DDR. Th
 erefore\, determining the interplay between the DDR and chromatin is funda
 mental for elucidating how cells maintain both epigenetic and genome integ
 rity. These issues are critical in diseases including cancer where genome 
 and epigenome instability are hallmarks of this disease. In addition\, man
 y cancer therapies function through damaging DNA and drugs that target the
  cancer epigenome are being developed as innovative therapeutic strategies
 .  Therefore\, our research aims to understand genome maintenance and the
  DNA damage response in the context of chromatin\, cancer and anticancer t
 herapies. The lab applies a multifaceted and diverse approach including ge
 netics\, genomics\, cell biology and molecular biology in mammalian cells 
 to study and define the relationship between chromatin and DNA damage resp
 onses\, as well as to gain insights into the mechanisms of cancer therapeu
 tic drugs that act at the chromatin and DNA level. Our current work relate
 d to these topics will be presented.
LOCATION:SV1717.1 http://plan.epfl.ch/?q=SV1717a
STATUS:CONFIRMED
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