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SUMMARY:Involvement of the noradrenergic system in the basolateral amygdal
 a during olfactory trace conditioning in the rat
DTSTART:20091116T160000
DTSTAMP:20260503T112507Z
UID:535356f403714857dc9bfb07064dbce1be2de4666f997e4b48a31294
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Barbara Ferry\nAbstract\nConditioned odor aversion (COA) c
 orresponds to the avoidance of an odorized-tasteless solution (conditioned
  stimulus\, CS) previously paired with toxicosis (unconditioned stimulus\,
  US). COA occurs only when the interstimulus interval (ISI) is kept short 
 during acquisition\, suggesting that the memory trace of the odor is subje
 ct to rapid decay. Previous studies have shown that the basolateral amygda
 la (BLA) is involved in the control of the olfactory memory trace during t
 he acquisition of COA. More recently\, pre-CS but not post-CS or pre-test 
 blockade of ƒÒ- adrenoceptors in the BLA disrupted COA\, thus suggesting
  that the noradrenergic system is involved\, at least in part\, in the pro
 cesses that control the memory trace of the CS during COA acquisition. Mor
 eover\, manipulation of the a1- and a2-adrenoceptor system in the BLA duri
 ng acquisition of COA showed that the olfactory memory trace duration duri
 ng COA is also under control of a1 and a2 adrenergic receptor signalling p
 athways. \nIn reference to in vitro electrophysiological data\, one could 
 acurately suggest that the noradrenergic system arising from the locus coe
 ruleus exerts\, at least in part\, a tonic inhibitory influence on the str
 uctures involving the BLA that are important for the olfactory information
  storage. The behavioral relevance of this adrenergic modulation must be s
 ubtle and this system may be involved in the way the animal makes a contra
 st between surrounding odors\, thus enabling it to keep them in memory for
  a long time as far as these odors are likely to acquire a particular hedo
 nic valence during learning.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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