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SUMMARY:Microbiome and the Brain : A paradigm shift in the understanding o
 f neurodevelopment and behaviour
DTSTART:20160916T110000
DTEND:20160916T120000
DTSTAMP:20260510T020848Z
UID:01e99c4aff318df76bf4e36452f460bc2b19ce52dab839470cfe5a13
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. John Cryan  \n\nDepartment anatomy & Neuroscience Univers
 ity College Cork\, Ireland\n\n \n\nThe brain-gut-microbiota axis is emerg
 ing as a research area of increasing interest for those investigating the 
 biological and physiological basis of neurodevelopmental\, age-related and
  neurodegenerative disorders. The routes of communication between the gut 
 and brain include the vagus nerve\, the immune system\, tryptophan metabol
 ism\, via the enteric nervous system or by way of microbial metabolites su
 ch as short chain fatty acids. Studies in animal models have shown that th
 e development of an appropriate stress response is dependent on the microb
 iota. Developmentally\, a variety of factors can impact the microbiota in 
 early life including mode of birth delivery\, antibiotic exposure\, mode o
 f nutritional provision\, infection\, stress as well as host genetics. At 
 the other extreme of life\, individuals who age with considerable ill heal
 th tend to show narrowing in microbial diversity. Stress can significantly
  impact the microbiota-gut-brain axis at all stages across the lifespan Re
 cently\, the gut microbiota has been implicated in a variety of conditions
  including autism\, schizophrenia and Parkinson’s disease. Moreover\, fu
 ndamental brain processes from adult hippocampal neurogenesis to myelinati
 on to microglia activation have been show to be regulated by the microbiom
 e. Further studies will focus on understanding the mechanisms underlying s
 uch brain effects and developing nutritional and microbial-based intervent
 ion strategies.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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