BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Elucidating the functions and mechanisms of inositol pyrophosphate
  messengers with chemical tools
DTSTART:20160208T160000
DTEND:20160208T180000
DTSTAMP:20260428T004613Z
UID:8e23dcd3487e180d26457fbbd5d3b1763c254d8b59099161ee42a15e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dorothea Fielder\, FMP Berlin\nBy integrating signaling 
 cues with metabolic status\, cells are able to modulate a range of process
 es according to their internal resources. The diphosphoinositol polyphosph
 ates (PP-InsPs) are a unique group of highly phosphorylated messengers kno
 wn to control glucose uptake\, insulin signaling\, and energy homeostasis\
 , and thereby provide an important link between signaling and metabolic ne
 tworks. It is thought that PP-InsPs exert their pleiotropic effects as all
 osteric small molecule regulators and via pyrophosphorylation of protein s
 ubstrates\, but most details in PP-InsP signaling have remained elusive du
 e to a paucity of suitable reagents.\nOur group is taking chemical approac
 hes to uncover the molecular mechanisms in PP-InsP signaling. We have desi
 gned non-hydrolyzable PP-InsP analogues and have utilized these analogs fo
 r the affinity purification of inositol polyphosphate binding proteins. In
  parallel\, we devised a method that provides easy access to pyrophosphope
 ptides. The pyrophosphopeptides were subsequently employed for the develop
 ment of specific enrichment procedures and for mass spectrometry-based det
 ection of endogenous pyrophosphoproteins. Overall\, our data contributes t
 o a better understanding of the complex PP-InsP signaling landscape\, and 
 suggests that the inositol pyrophosphates can intersect with signaling and
  metabolic pathways via two distinct mechanisms.
LOCATION:CM01 http://plan.epfl.ch/?lang=fr&room=cm1
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR