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SUMMARY:Transcriptional regulation of lipid biosynthesis in mycobacteria
DTSTART:20111201T160000
DTSTAMP:20260916T070057Z
UID:7e6d14470228e86715edd3c45054d49b2884d2f3ed9f9d3b7591eca3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Hugo Gramajo (Instituto de Biologia Molecular y Celular d
 e Rosario\, Argentina)\nMycobacterium tuberculosis remains a major human p
 ublic health threat. The success of this pathogen largely stems from its r
 emarkable capacity to survive within the infected host\, being its unusual
  cell wall a key factor in this survival. Mycobacteria cell wall biosynthe
 sis involves two structural distinct fatty acid synthase systems\, FAS-I a
 nd FAS-II\, which should work in a finely coordinate manner to keep lipid 
 homeostasis tightly regulated. The main purpose of our studies is to under
 stand how mycobacteria exert this exquisite control over the biosynthesis 
 of their membrane lipids and find out the key components of the regulatory
  network that control fatty acid and mycolic acid biosynthesis at the tran
 scriptional level. Here\, we present the in vivo an in vitro characterizat
 ion of MabR\, the transcriptional regulator of the fasII operon\, and of F
 asR\, a new regulatory protein that specifically binds pfas to regulate th
 e de novo fatty acid biosynthesis. We also present evidences that long-cha
 in acyl-CoAs are the effector molecules that co-ordinates the expression o
 f the two FAS systems at the transcriptional level.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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