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SUMMARY:Adapting to Mitochondrial Dysfunction via Inter-Organelle Communic
 ation
DTSTART:20160201T121500
DTSTAMP:20260407T043711Z
UID:df3651a69d9559694398003fc9876a5ab424b40cbfc510cecfa34487
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Cole M. Haynes\, Memorial Sloan Kettering Cancer Center\
 , New York\, NY (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING(san
 dwiches served)Abstract:\nDuring metazoan development and cell specificati
 on\, mitochondrial biogenesis is tailored to match the physiologic require
 ments of individual cell types. Loss of mitochondrial activity\, or mitoch
 ondrial dysfunction\, is tightly linked with a number of seemingly dispara
 te pathologic scenarios including neurodegeneration\, cancer\, diabetes an
 d bacterial infection.\nMy laboratory is interested in how cells evaluate 
 mitochondrial function and adapt to survive and ultimately recover from mi
 tochondrial stress. We focus on a mitochondrial-to-nuclear signaling pathw
 ay known as the mitochondrial unfolded protein response (UPRmt) that regul
 ates a transcriptional response to repair and recover defective mitochondr
 ia. Considerable progress has been made in understanding how cells evaluat
 e mitochondrial function and respond accordingly\, however physiologic rol
 es of this stress-activated signal transduction pathway are only emerging.
 \nHere\, I’ll discuss a protective role for the UPRmt as a bona fide inn
 ate immune response during infection by those bacteria that perturb mitoch
 ondrial function. This will be contrasted with a potentially detrimental r
 ole for the UPRmt in the propagation of deleterious mitochondrial genomes 
 that may contribute to the mitochondrial deterioration observed in the abo
 ve-mentioned age-associated diseases.Bio:Education:\n2003 Ph.D. Cell Biolo
 gy and Biophysics\, University of Missouri Kansas City\n1998 B.S. Biology\
 , Truman State UniversityResearch Experience:\n2009-present\nAssociate Mem
 ber\nCell Biology Program\nMemorial Sloan Kettering Cancer Center\, New Yo
 rk\, NY\nAssociate Professor\, Gerstner Sloan-Kettering Graduate School\nA
 ssociate Professor\, BCMB Program\, Weill Cornell Medical College\n2004-20
 09\nPostdoctoral Fellow\nNew York University\, Laboratory of David Ron\n
 “Identification and Characterization of UPRmt Signaling Components”\n1
 998-2003\nGraduate Student\nUniversity of Missouri-Kansas City\, Laborator
 y of Antony Cooper\n“Protective adaptations to endoplasmic reticulum dys
 function”
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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