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SUMMARY:Modeling synaptic plasticity across different time scales: the inf
 luence of voltage\, spike timing\, and protein synthesis
DTSTART:20091009T121500
DTSTAMP:20260407T011337Z
UID:7f2313e0629b4920bc8427f60238af16f002cb7283baad381181418d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Claudia Clopath\, EPFL\nChanges in synaptic efficacies nee
 d to be long-lasting in order to serve as a substrate for memory. Experime
 ntally\, synaptic plasticity exhibits phases covering the induction of lon
 g-term potentiation and depression (LTP/LTD) during the early phase of syn
 aptic plasticity\, the setting of synaptic tags\, a trigger process for pr
 otein synthesis\, and a slow transition leading to synaptic consolidation 
 during the late phase of synaptic plasticity. We present a mathematical mo
 del that describes these different phases of synaptic plasticity. The mode
 l explains a large body of experimental data on synaptic tagging and captu
 re\, cross-tagging\, and the late phases of LTP and LTD. Moreover\, the mo
 del accounts for the dependence of LTP and LTD induction on voltage and pr
 esynaptic stimulation frequency. The stabilization of potentiated synapses
  during the transition from early to late LTP occurs by protein synthesis 
 dynamics that is shared by groups of synapses. The functional consequence 
 of this shared process is that previously stabilized patterns of strong or
  weak synapses onto the same postsynaptic neuron are well protected agains
 t later changes induced by LTP/LTD protocols at individual synapses.
LOCATION:BC 01 https://plan.epfl.ch/?room==BC%2001
STATUS:CONFIRMED
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