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PRODID:-//Memento EPFL//
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SUMMARY:Adult hippocampal neurogenesis: functional implications for memory
  processing
DTSTART:20091111T121500
DTSTAMP:20260406T030029Z
UID:b7811367f396905d91a0a1a171f979878d3a0e15924f8fb79eae5a8e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Claire Rampon\, Centre de Recherches sur la Cognition Anim
 ale\, Toulouse France.\nHost : J.-P. Petit\n\nNew neurons are generated th
 roughout adult life in discrete regions of the mammalian brain\, including
  the dentate gyrus of the hippocampus. Some of these newborn neurons becom
 e integrated into pre-existing hippocampal circuits\, raising the possibil
 ity that they may contribute to behaviorally relevant neuronal assemblies.
  In this aim\, we examined whether new neurons born before learning may pa
 rticipate to the retrieval of remotely-acquired spatial memories\, we used
  activity-dependent mapping of the immediate early gene expression and vis
 ualized the recruitment of new neurons in a set of controlled water-maze p
 rocedures in mice. We established that adult-born neurons constitute a spe
 cific pool of cells destined to undergo activity-dependent plastic changes
  involved in the elaboration of neuronal networks underlying remote spatia
 l memories. Then\, we examined whether the inability to acquire and store 
 new information in pathological situation may be related to impaired adult
  hippocampal neurogenesis. We used transgenic mice models of Alzheimer’s
  disease to address this question.
LOCATION:AI 1 153
STATUS:CONFIRMED
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