BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:"Single Bead\, Single Molecule and Single Cell Chemical Biology"
DTSTART:20091006T160000
DTSTAMP:20260415T235734Z
UID:b39c5560ce46c110a953d47bf26737d8cd51503e9ffa06e169f44691
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Manfred Auer\, Centre for Translational and Chemical Bio
 logy (CSE) & Division of Pathway Medicine (CMVM)\, Edinburgh Univ.\nAbstra
 ct: The discovery of lead compounds for pharmaceutical development and the
  identification of tool compounds for basic science applications is an int
 erdisciplinary exercise that integrates chemistry\, physics\, engineering\
 , computer science\, and both biochemical and clinical biomedicine. During
  recent years we has assembled\, explored and exploited a unique miniaturi
 zed small molecule discovery platform that comprises steps from design\, t
 heoretical and experimental target analysis\, high throughput chemical syn
 thesis and screening to quantitative mechanistic studies of compound actio
 n in cells. This “chemical biophysics” technology is based on single m
 icro bead analysis linked to single molecule scanning\, spectroscopy and i
 maging for primary screening and quantitative compound confirmation in sol
 ution. Single cell micro-spectroscopy is applied for cellular mechanistic 
 characterisation of validated hits. The integration of these methods enabl
 es high throughput hit and lead discovery at very low cost (< 1/1000 of  c
 onventional pharma-style screens). All process steps are thoroughly quanti
 tative and quality controlled. The screening platform is run on four bespo
 ke confocal microspectroscopes\, a  LEAP and a COPAS instrument\, amongst 
 many additional biophysical instruments.  In our “science by screening
 ” approach we focus our efforts on new strategies to tackle inhibition o
 f protein – protein interactions\, on identification of allosteric modul
 ators and on the use of the newly discovered small molecule and peptidomim
 etics for solving mechanistic questions in mRNA stability regulation and r
 eceptor triggering mechanisms.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR