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SUMMARY:Droplet-Based Microfluidics for Synthetic Biology Applications
DTSTART:20160229T121500
DTSTAMP:20260528T120315Z
UID:7c97cc7ec19167dd4deec105bbd8235cd39e9b7408bb792dd26486a9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ilia Platzman\, Ph.D.\, MPI for Intelligent Systems\, Stuttgar
 t (D) and University of Heidelberg (D)\nBIOENGINEERING SEMINARAbstract:\nC
 ellular interactions with the extracellular matrix or other cells are invo
 lved in nearly every cellular response in vivo. These responses\, in turn\
 , affect nearly all facets of cell’s life\, including\, but not limited 
 to\, directional migration\, cell proliferation\, differentiation\, surviv
 al and gene expression. This broad range of adhesion/interaction-mediated 
 processes also underscores their central physiological roles\, as well as 
 their involvement in a wide variety of disease states. Although attaining 
 a fundamental characterization of these cellular functions is a compelling
  goal\, the extensive complexity of these processes has hindered a full un
 derstanding. Therefore\, engineering of biomimetic systems for controlled 
 manipulation of individual cells or subcellular units in vitro has become 
 an important strategy. This synthetic approach can contribute to the under
 standing of the mechanisms underlying the ability of cells to perform “i
 ntelligent” missions\, such as acquiring\, processing and responding to 
 environmental information.\nIn this lecture I will describe our approaches
  to dissect complex cellular sensory machinery by means of an automated\, 
 high-throughput droplet-based microfluidic technology. Specifically\, I wi
 ll focus on the capacities of this technology in the following topics: 1) 
 Bottom-up assembly of “droplet-based synthetic cells” capable to self-
 assemble different cytoskeletal and adhesion associated proteins\, and\, a
 s a consequence\, to generate signaling events including actin filament or
 ganization and self-propelling\; and 2) mimicry of the immune system cellu
 lar environment for adoptive T cell therapy\, with the goal of programing 
 T cells to combat diseases like cancer.Bio:\nEducation:\nB.Sc.  2001 - 20
 05  Technion – Israel Institute of Technology (IIT)\, Haifa\, Israel\, 
 the Department of Chemical Engineering\, Cum Laude.\nPh.D. direct track  
 2005 - 2010  Technion – IIT\, Haifa\, Israel\, the Department of Chemic
 al Engineering. Advisors: Professor Rina Tannenbaum and Professor Hossam H
 aick. Title of thesis: “Self-Assembly of Organic Thin Films as Interacti
 ve\, Bridging and Conductive Layers for Nanoelectronic Applications.”\nE
 mployment History:\n2014 -  Project Leader\, Max Planck Institute for Int
 elligent Systems (MPI-IS)\, Stuttgart\, and the Department of Biophysical 
 Chemistry\, University of Heidelberg\, Heidelberg\, Germany.\n2013 - 2014
   Max Planck Senior Postdoctoral Researcher\, MPI-IS\, Stuttgart\, and th
 e Department of Biophysical Chemistry\, University of Heidelberg\, Heidelb
 erg\, Germany.\n2010 - 2013  Postdoctoral Research Fellow\, MPI-IS\, Stut
 tgart\, and the Department of Physical Chemistry\, University of Heidelber
 g\, Heidelberg\, Germany.
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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