BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Chaperoning Single Proteins
DTSTART:20160304T121500
DTSTAMP:20260407T105353Z
UID:9f2df1c33ee4ebf7d4c9b28b6c9ede698fba079da02d8a8d3b83c5a5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sander J. Tans\, AMOLF\, Amsterdam (NL)\nSEMINARS IN BIO
 LOGICAL PHYSICSAbstract:\nVarious chaperones are known to bind exposed pro
 tein chains\, and hence protect them from aggregation before folding start
 s\, and to rescue them when they are misfolded. Using optical tweezers\, w
 e explore how chaperones affect the stability and structure of transient f
 olding intermediates. We show that various chaperones interact directly wi
 th folded protein structures\, and hence actively help solve their conform
 ational search for the native state. They exploit diverse mechanisms\, ran
 ging from stimulating local folding to ATP-driven capture and release of p
 artially folded protein structures. The results indicate that chaperones p
 erform more intricate tasks than previously assumed\, and bring a new pers
 pective to the protein-folding problem.Bio:\nEducation:\nPh.D. in Physics\
 , Dekker group\, Delft University of Technology\, 1998\nHighest honors\, T
 hesis title: ‘Electron transport in single molecular wires’\nM.Sc. in 
 Physics\, Mooij group\, Delft University of Technology\, 1993\nM.Sc. in Ap
 plied Physics\, Université Jussieu\, Paris\, 1991\nPositions:\n2001–pre
 sent\nGroup leader\, FOM-Institute for Atomic and Molecular Physics (AMOLF
 )\, Amsterdam\, NL\n2009–present\nProfessor\, Kavli Institute of NanoSci
 ence\, Bionanoscience department\, Delft University of Technology\, NL\n19
 99–2001\nPostdoctoral research fellow\, Carlos Bustamante group\, Univer
 sity of California at Berkeley\, USA\n1999\nPostdoctoral research fellow\,
  Cees Dekker group\, Delft University of Technology\, NL\n1998–1999\nI.B
 .M. Netherlands
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR