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SUMMARY:Inference of Disease Genes from Protein Interactions in trans and 
 cis 
DTSTART:20160314T121500
DTSTAMP:20260506T221354Z
UID:8ab87c66461e4bf89776f2f312e54326e20429394524ad86acfe7f17
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jörg Gsponer\, University of British Columbia (UBC)\, V
 ancouver (Can)\nBIOENGINEERING SEMINAR(sandwiches served)Abstract:\nProtei
 n interactions in trans and cis that activate or inhibit protein function 
 play an important role in the fine-tuning of regulatory and signaling proc
 esses in the cell. In the first part of my presentation\, I will show how 
 we integrated data on protein interaction in trans with genomic informatio
 n on risk genes of neurodegenerative diseases in order to identify genes t
 hat may increase the risk to develop any type of neurodegenerative disease
  when altered in expression or sequence. In the second part\, I will intro
 duce a computational approach for the identification of intrinsically diso
 rdered cis-regulatory elements (CREs)\, i.e.\, protein segments that regul
 ate protein function via interactions in cis\, and demonstrate that diseas
 e-causing mutations are highly enriched in predicted CREs\, specifically m
 utations that are associated with different cancers.Bio:\nEducation:\n2003
  – 2006\nUniversity of Cambridge (UK)\nPost-doctoral Fellow\, Computatio
 nal Chemistry\n1998 – 2003\nUniversity of Zurich (CH)\nDoctor of Philoso
 phy (PhD)\, Computational Biophysics\n1991 – 1997\nUniversity of Lausann
 e (CH)\nDoctor of Medicine (MD)\, Medicine\nPositions:\n2015 – Present\n
 Roche\, Basel (CH)\nVisiting Professor\n2015 – Present\nUniversity of Br
 itish Columbia (UBC)\, Vancouver (Can)\nAssociate Professor\n2009 – 2015
 \nUBC\, Centre for High-Throughput Biology (CHiBi)\nAssistant Professor\n2
 006 – 2009\nMRC Laboratory of Molecular Biology\, Cambridge (UK)\nResear
 ch Fellow
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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