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SUMMARY:Bacillus subtilis as a Tool in Basic Science and Applied Research
DTSTART:20120221T161500
DTSTAMP:20260503T153811Z
UID:8263420e792f793027d7e5a3af5145373b95f640880d54935cfe7cbb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Imrich Barack\, Slovak Academy of Science\, Institute of Molec
 ular Biology \, SL\nBacillus subtilis is an internationally-recognised mod
 el microorganism\, whose physiology\, biochemistry and genetics has been s
 tudied for decades. Our research is oriented toward studying the proteins 
 involved in basic processes in B. subtilis as cell division\, sporulation 
 and programmed cell death. The lecture will cover broad range of results e
 xplaining the mechanism of the basic cell processes in B. subtilis and its
  potential in biotechnological exploitation. It will concentrate on basic 
 science questions as i) How the cell knows with high precision to find its
  centre? ii) How the cell knows when to start to sporulate? iii) How the a
 symmetry in gene expression is programmed? iv) Why the unicellular organis
 m is programmed for self destruction? The main focus of the lecture will b
 e on the lipid and protein structures what control cell division and sporu
 lation. The domains of different lipid composition are present in eukaryot
 ic and prokaryotic cell membranes. Using membrane binding fluorescent dyes
 \, we demonstrated previously\, the presence of lipid spirals extending al
 ong the long-axis of cells of the rod-shaped bacterium B. subtilis. These 
 data indicate a higher level of membrane lipid organization than previousl
 y observed. Little is known however of the origin of these helical structu
 res. Principally\, there are at least three main specifically localized mo
 lecular structures in the membrane or close proximity to it – peptidogly
 can layer\, membrane proteins and cytoskeleton structures and all of them 
 can help to form or influence the formation of lipid helixes. The role of 
 the lipid domains in regulation of cell division through the Min system wi
 ll be discussed in details.
LOCATION:GR A3 31 http://plan.epfl.ch/?room=GR%20A3%2031
STATUS:CONFIRMED
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