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SUMMARY:Protein transport by the bacterial Tat pathway
DTSTART:20160503T121500
DTSTAMP:20260922T042826Z
UID:36d049fd46bebb50a636213fe4854ebbcc322c442bd845e4133bd274
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Tracy Palmer\, University of Dundee\, Scotland\nThe Tat 
 protein transport system functions to export folded proteins across the ba
 cterial cytoplasmic membrane. Many Tat substrate proteins bind complex met
 al cofactors and the Tat pathway is required for important bacterial cellu
 lar processes including respiration and photosynthesis\, cell division\, m
 otility and iron and phosphate acquisition. The Tat system is found in man
 y animal and plant bacterial pathogens where in most cases it is required 
 for virulence.\nProteins are targeted to the Tat system by N-terminal sign
 al peptides that contain a conserved twin arginine motif. Our studies with
  the model organism Escherichia coli have shown that the integral membrane
 s proteins TatA\, TatB\, and TatC form essential components of the transpo
 rt machinery. Multiple copies of TatB and TatC associate to form a large T
 atBC complex that recognises twin-arginine signal peptides and binds subst
 rate proteins. Binding of substrate proteins to TatBC triggers polymerizat
 ion of TatA to form the transmembrane translocation pathway.\nRecently the
  crystal structure of the TatC component from Aquifex aeolicus has been de
 termined. TatC contains six closely-packed transmembrane helices forming a
  central cavity on one face of the protein overhung by an extensive peripl
 asmic cap [1]. This structure forms a framework for understanding the loca
 tion and dynamic nature of the binding sites for the TatA and TatB partner
  proteins and the twin-arginine signal peptide. We have been using a combi
 nation of molecular biology\, suppression genetics and cross-linking studi
 es to explore the molecular interactions between the Tat components at dif
 ferent stages of the Tat translocation cycle. Our latest findings will be 
 presented.\n1.        Rollauer\, S.E.\, et al. Nature 2012\, 492\, 
 210-214.\nBio: Since 2007 - Professor of Molecular Microbiology\, Head of 
 the Division of Molecular Microbiology\, College of Life Sciences\, Univer
 sity of Dundee\n2004-2007 - MRC Senior Non Clinical Research Fellow based 
 at John Innes Centre\, Norwich\n1996-2004 - Royal Society University Resea
 rch Fellow based at John Innes Centre\, Norwich\n1993-1996 - University Re
 search Fellow\, Department of Biochemistry\, University of Dundee\n1992-19
 93 - Postdoctoral Research Assistant\, University of Dundee with Prof D.H.
  Boxer\n1988-1991 - Research Associate (RA1B) and PhD student\, University
  of Birmingham with Prof J.B. Jackson\n1988-1991 - Postgraduate:Ph.D. Bioc
 hemistry\, University of Birmingham\n1985-1988 - Undergraduate:B. Sc. Bioc
 hemistry (First Class Honours)\,University of Birmingham
LOCATION:SV 1717a http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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