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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Linking functional genomics and genetic epidemiology association s
 tudies to biological responses and clinical phenotypes in leprosy
DTSTART:20160415T140000
DTEND:20160415T150000
DTSTAMP:20260407T114626Z
UID:55f0fc5db6e95068172412c44d0e7532a68d8cf5ae4917337bb38b06
CATEGORIES:Miscellaneous
DESCRIPTION:Milton O. Moraes\n\nLarge-scale analyses have changed the scen
 ario of infectious diseases studies revealing novel pathways and genes as 
 associated with specific phenotypes of chronic infectious disease such as 
 leprosy and tuberculosis. Then\, the ability to test using monocyte in vit
 ro infections with live M. leprae targeting novel main genes are enabling 
 to disclose fully new strategies that mycobacteria developed to subvert pr
 otective immune response and drive intracellular environment into a safe n
 iche to replicate and survive. M.leprae infection triggers a combination o
 f signals connecting routes like type-I interferon\, lipid and energy meta
 bolism with autophagy.  In this context\, major genes regulating innate\,
  adaptive and metabolic responses define in one hand pro-mycobacterial or\
 , in the other hand\, protective responses in a way that genetic polymorph
 isms could participate in the definition of the susceptibility status of p
 atient.
LOCATION:CM 1112 http://plan.epfl.ch/?lang=fr&zoom=20&recenter_y=5864168.1
 8802&recenter_x=730975.81136&layerNodes=fonds\,batiments\,labels\,informat
 ion\,parkings_publics\,arrets_metro\,transports_publics&floor=1&q=CM_1112
STATUS:CONFIRMED
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